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This reduced stability window occurs because the aqueous environment facilitates chemical reactions that don't occur in the dry powder form

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Yes, and many clinical protocols do exactly this

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doi:10.1093/advances/nmab141

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Impairment of insulin signaling in the liver, skeletal muscle and adipose tissue can lead to hyperglycemia, persistent high blood sugar levels can lead to cellular damage in the kidneys, potentially resulting in chronic kidney injury and speeding up the progression of DKD (Bai et al., 2025)

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