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Effective delivery systems including needles, syringes, auto-injectors, and containment vialsare critical for patient adherence, dosing accuracy, and safety

Common issues include nausea, vomiting, constipation, or diarrhea from GLP-1 agonists, and insomnia, dry mouth, or jitteriness from stimulants

The STEP trials were not designed or powered to detect fracture risk, so that signal exists in the background of the most-cited efficacy data, largely unmeasured

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