Among the possible recombinant GIP analogues, the analogues that simultaneously conserve Tyr 1 and Ile 7 show similar GLP-1R-activating activity to natural GIP, and Ile 7 is more important than Tyr 1
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Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling
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