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In addition, sulfonylureas interact directly with myocardiocytes, blocking an ATP-dependent potassium channel involved in myocardial adaptation to ischaemia69

The first approach is the Loading Phase

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Charman SA, Charman WN, Rogge MC, Wilson TD, Dutko FJ, Pouton CW

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Similarly, nondifferential misclassification of binary exposures and outcomes, as seen in claims data-based studies, tends to bias effect estimates toward the null 44