The importance of change in GLP-1 users' skin and the concerns of dryness, loss of visible firmness, and changes in texture cannot be overstated, says Julius Few, MD, a plastic surgeon who practices in Chicago, Los Angeles, and New York
Given that retatrutide produced nearly 29% weight loss, more than any existing drug, the faster review is possible
If the FDA stays on this schedule, orforglipron is likely to receive approval in early-to-mid 2026
The underlying pathophysiology of this early worsening is believed to involve hemodynamic shifts in a retinal microvasculature that has lost its capacity for autoregulation
Because it works this way on different metabolic pathways, retatrutide is becoming a strong option in new weight loss medicines
The brand's "Reactivate Your GLP-1" phrase refers to botanical support for natural GLP-1 hormone pathway wellness, not delivery of a prescription compound through skin