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This is the proportion observed in the SURMOUNT-1 tirzepatide trial across age, sex, and weight-loss subgroups, and was similar for placebo participants who lost weight without medication 2

(2008), measures of enzyme activity were used (creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase), allowing a gauge of trauma response (proteolysis) and therefore the ability to further understand the mechanisms of action

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