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Source: Prkacin et al., 2001 Multi-Organ Protection: Brain, Liver, Kidney, Lung The most comprehensive study came from Gojkovic et al

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Immunohistochemical staining and western blot analysis revealed that SNL increased the activation of microglia and astrocytes in the dentate gyrus of the hippocampus, along with elevated expression of pro-inflammatory cytokines such as TNF-, IL-1 and IL-6, which were significantly reversed by exendin-4 treatment [68]

The GFR is approximately 20% of renal blood flow in a healthy kidney

J Matern Fetal Neonatal Med