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These are patterns from real-world reports rather than trial incidence rates

Compare Tirzepatide and Semaglutide

Researchers caution that these results come from controlled clinical trials and may not translate directly to real-world use

Tolerability issues leading to dose reductions may limit the therapeutic benefit achievable in some patients

Nature 444 , 840846 (2006)

Quick answer: In the Phase 2 clinical trial (Jastreboff et al., 2023, New England Journal of Medicine ), retatrutide was given by once-weekly subcutaneous injection across a 112mg range