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In addition, the first-in-class compounds targeting novel bacterial targets, such as afabicin (Phase II), block fatty acid synthesis in Staphylococcus spp by inhibiting FabI, an enoyl-acyl carrier protein reductase [262] and murepavadin that inhibits an outer membrane protein (lipopolysaccharide transport protein, LptD of P

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[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Hsiao E.Y

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