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Antioxidant Depletion: In an ironnitrilotriacetic acid rat model of hemochromatosis, renal samples showed increases in reactive intermediates, accompanied by decreased availability of systems that protect against oxidation by iron, such as vitamin E levels, the glutathione system, thiol-specific antioxidants, and superoxide dismutase

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In an animal model, NAC increased lung cancer cell proliferation due to its antioxidant activity by reducing ROS, DNA damage, and p53 expression (36)

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The pattern may justify reviewing dose, interactions, organ function and the underlying biochemical burden with the prescribing clinician