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the 23 March 2026 Pfizer/Valneva VLA15 (PF-07307405) Phase 3 VALOR readout (73.2% efficacy)

TSH is the most sensitive marker of thyroid status change

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The Key Takeaways: Most common: Nausea (43%), manageable with dietary changes and timing Unique: Dysesthesia (20.9%), mild tingling sensations, not seen with Wegovy/Mounjaro Timeline: Worst during dose escalation (weeks 116), significant improvement after Discontinuation: 18.2% in TRIUMPH-4, 11.3% in TRIUMPH-1 the general obesity population tolerates it better than the osteoarthritis cohort Reversible: Stopping medication reverses side effects For most people with obesity especially severe obesity the 28.328.7% weight loss and associated health benefits outweigh the temporary discomfort during the first few months

It's made from three amino acids arginine, glycine, and methionine but it is also found in meat and fish, or can be taken as a supplement

Unlike when you eat the right foods or take supplements with the IV 100% of the goodness is absorbed into the bloodstream