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The "as needed" approach reflects that NAD+ is a coenzyme, not a receptor agonist there's no desensitization concern in the same way
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If you take 2000 mcg or more of adenosylcobalamin with hydroxocobalamin, you may get too much vitamin B12
FDA approval costs hundreds of millions to over a billion dollars, a bet pharma only makes when there's a patent to protect
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