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Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]

The GSH:GSSG ratio is a primary indicator of oxidative stress

Cherry JD, Olschowka JA, OBanion MK

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