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J Neuropathol Exp Neurol 59:314322

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Under hypoxia or mitochondrial dysfunction, -KG can be converted to citrate by Isocitrate dehydrogenase (IDH 2) catalyzed carboxylation reaction, which is used for the synthesis of amino acids and fatty acids and the production of reducing agent NADPH

Neuronal compartmentalization results in impoverished axonal mitochondria