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Their biology has changed

Primary Sjgren syndrome in Han Chinese: clinical and immunological characteristics of 483 patients

Waters Corp., Milford, MA, United States)

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10.1016/j.psyneuen.2019.02.006 57 VallofD.KalafateliA

It acts as a dual agonist at amylin receptors (AMY1R, AMY2R, AMY3R, formed by calcitonin receptor heterodimerized with RAMP1-3) and calcitonin receptors, with structural modifications (e.g., N-terminal fatty acid acylation, proline substitutions) preventing fibril formation, enhancing stability, and enabling once-weekly dosing via albumin binding for prolonged circulation