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The overall structure of active GLP-2RG s complex is similar to other class B GPCRG s complexes such as GLP-1GLP-1RG s , 13 ExP5GLP-1RG s , 17 glucagonGCGRG s , 18 LA-PTHPTH1RG s 19 and GHRHGHRHRG s , 26 with root mean square deviation (RMSD) values of 1.76, 1.05, 1.55, 1.09 and 0.95 for the whole complex, respectively

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This corrected matrix was then analysed using DESeq2 to calculate the adjusted P value in the covariate model

- *Implications for Treatment*: Understanding the connection between Demodex toxins and ACPA could lead to new treatment approaches, such as targeting Demodex mites or their toxins to modulate the autoimmune response

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