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High resolution ultrasound imaging scan was performed to monitor dimension of developing tumor lesions using Vevo 3100 System (VisualSonics, Amsterdam, The Netherlands)

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Although the study did not distinguish the efficacy among different heterozygous LMP variants, it confirmed that heterozygous mutations in the LMP pathway (including MC4R ) are associated with compromised long-term surgical outcomes, consistent with the findings in heterozygous MC4R P/LP variant carriers

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