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e , The distances between catalytic residues Sec46 and Trp136 were recorded every 4.8 ps throughout MD simulations of GPX4 WT (PDB: 6HN3), GPX4 K48A , GPX4 K48L , GPX4 K48E , GPX4 K48Q , and GPX4 K48R

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KPV is also stable at -20C

Physiopathological functions of GPx and associated diseases The increase of ROS has been associated with the appearance and progression of aging and related diseases including arthritis, diabetes, dementia, cancer, atherosclerosis, and vascular diseases, which are inflammatory disorders, a consequence of oxidative stress [54, 55]

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