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LDN is most often considered in patients with refractory, multisystem presentations where broader neuroimmune or immunomodulatory strategies are being explored

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It adds a 13-amino-acid extension at the N-terminus and substitutes arginine for glutamic acid at position 3, which sharply reduces its binding to IGF binding proteins [1] [2]

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I have found smaller doses (500mcg/injection) more frequently is right for me

We can argue about various toxic processed oils, herbicide-laden carbohydrates, and the other fat-soluble molecules in our diets that drive insulin resistance all day long, but regardless of where you stand on those, or whether you're into low-fat or high-fat dieting, you must keep protein high