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Setmelanotide is an 8-amino acid cyclic peptide analog of -MSH that promotes weight loss by activating MC4R to reduce hunger, thereby decreasing caloric intake and increasing energy expenditure [50]

including semaglutide branded as Wegovy or Ozempic, and tirzepatide (dual GIP/GLP-1 receptor agonist) branded as Zepbound or Mounjaro, for the management of obesity, type 2 diabetes, and other metabolic conditions increases, so too does the need to assess the advantages and potential downsides of long-term use

Rare but serious risks include pancreatitis (requiring immediate medical attention if severe abdominal pain occurs), gallbladder disease, and potential thyroid C-cell tumors (based on rodent studies)

Initiation of GLP-1 receptor agonists in post-bariatric patients follows similar protocols to other populations, with gradual dose escalation to minimise gastrointestinal side effects

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