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Shao N, Huang H, Idris M, Peng X, Xu F, Dong S, et al

Phosphorylated Smad2/3 complexes then translocate to the nucleus, where they induce transcription of fibrogenic genes, including collagen I/III, fibronectin, and -smooth muscle actin (-SMA)

"The glycolic acid works to gently exfoliate and even out skin tone while the niacinamide and tranexamic acid help to lighten the dark spots," she says

It is intended to treat mild to moderate whitening skin conditions and to prevent further staining and discoloration

Mononuclear cell from G6PD-deficient subjects show an increased DNA damage, e.g., a higher rate of apoptosis after UV irradiation owing to deficient ROS detoxification [161]

Clinical implications of this study need more investigation