glutathione and folate (as THF), vitamin B6, vitamin B12 are required for Glutathione crucial for MTHFR health

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Consistently, bacterial GSTs have been implicated in antibiotic resistance phenotypes

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Comparisons between the transgenic GSAAT1 substitution mutants and wild-type GSAAT1 expressed in the gsa2 background revealed a slightly reduced ALA synthesis capacity of leaf discs and in planta GSAAT activity of the leaf extracts only for the GSAAT(C190S) line ( Supplementary Figures 3C, E )