Hence, the low levels of thiomethyl metabolites observed after APAP exposure are probably associated to the limited cytochrome P450 capabilities of in vitro models to generate NAPQI metabolites via CYP2E compared to in vivo hepatocytes
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If gastrointestinal symptoms occur, several strategies may help, such as: Starting at a low dose and increasing gradually Eating smaller, more frequent meals Avoiding high-fat and high-fiber foods Staying well hydrated Temporarily pausing or adjusting the medication if needed In some cases, discontinuation may be necessary if symptoms are severe
H., Magrioti, V