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43 Similarly, semaglutide (0.5 or 1 mg once weekly) over two years in people with type 2 diabetes resulted in a 36% reduction in the progression of nephropathy compared with placebo

It's a "very infrequent" side effect, according to the company that makes it, but it can be permanent

Gallbladder disease is worth flagging separately

Without your physician's instruction, discontinuing these medications could result in worsening illness, injury, or death

This measure reflects average blood glucose over the past two to three months, and significant reductions indicate improved long-term blood sugar control

Generic manufacturers can begin challenging certain Zepbound patents via whats called a Paragraph IV certification starting in November 2027, but the most important patent for patients seeking the drug for weight loss is the one covering the use of tirzepatide for chronic weight management, which is in place until June 2039