Central regulation of energy metabolism by estrogens
Coskun and colleagues (Cell Metabolism, 2022) provided the foundational characterisation, demonstrating that balanced engagement of all three receptors produces metabolic effects not achievable through dual or single-receptor pharmacology alone
For instance, insulin doses may need to be reduced by 10 to 20 percent, depending on baseline control and risk factors
Livingston JA, Blay J-Y, Trent J, Valverde C, Agulnik M, Gounder M, et al
Chandler, K
All volunteers indicated a willingness to adhere to dietary restrictions: refraining from consuming cruciferous vegetables and condiments that might contain glucosinolates or isothiocyanates (e.g., prepared mustard aka deli mustard, mustard greens, horseradish, wasabi, mayonnaise