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Gastroenterology 162(4):13341342

Participants Eligibility criteria for participating in the study were: Septic ICU resident patients (diagnosed by sepsis-3 criteria), older than 18 years, having provided written informed consent, and being nourished enterally

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Haws RM, Gordon G, Han JC, Yanovski JA, Yuan G, Stewart MW

By increasing NAD levels and activating the SIRT1 pathway, NNMTi inhibits the activation of inflammatory signaling pathways (such as the NFB pathway), thereby reducing macrophage infiltration and inflammatory factor release