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Healthcare Cost Trends in New Users of SGLT-2i, DPP-4i and GLP-1 RA for Type 2 Diabetes: An Observational Longitudinal Study

Based on the provided examples, the structural changes compared to Orforglipron primarily involve both the indole ring and the oxadiazole ring in the side chain (W substituent)

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Cell Metab 13 , 320330, doi:S1550-4131(11)00045-310.1016/j.cmet.2011.02.001 (2011)