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Third, individual responses to GLP-1 class drugs vary some people are biologically more responsive than others

Clinically, steady state often correlates with a stabilization of side effects

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GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

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A meta-analysis of 113 RCTs comprising 33,167 patients in the GLP-1 RA cohort and 26,683 in the comparator cohort revealed no significant elevation in pancreatitis or pancreatic cancer risk relative to control groups (Mantel-Haenszel odds ratio [MH-OR] of 0.93 and 0.94, respectively), but identified a notable increase in cholelithiasis risk (MH-OR, 1.30) [58]