Lactic acidosis is a concerning side effect associated with Metformin in adults and occurs in the presence of hypoperfusion or hypoxemia (178)
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Subjects were 50 years of age with established CVD (defined as previous CV, cerebrovascular, or peripheral vascular disease), chronic heart failure (New York Heart Association class II or III), or chronic kidney disease (CKD) of stage 3 or higher, or were 60 years of age with at least one CV risk factor (microalbuminuria or proteinuria, hypertension and left ventricular hypertrophy, left ventricular systolic or diastolic dysfunction or anklebrachial index 65 years), and CV risk profile at baseline on time to first occurrence of MACE, the individual components of MACE (CV death, nonfatal MI, or nonfatal stroke), hospitalization for unstable angina or heart failure, and revascularization
[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Zhou Y.T., He W., Lo Y.M., Hu X., Wu X., Yin J.J
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Foundayo side effects and safety Common side effects The most frequently reported side effects are gastrointestinal, similar to other GLP-1 medications