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Research suggests the copper complex is the bioactive form copper appears essential for most documented biological activities

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The subsequent upregulation of HSPA5 increased the expression and activity of GPX4, which countered DHA-induced lipid peroxidation and protected glioma cells from ferroptosis

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Copperiedus could occur from consuming excess copper salts, but most commonly it is the result of the genetic condition Wilson's disease and Menke's disease, which are associated with mismanaged transport and storage of copper ions