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In experimental models of acquired epilepsy, such as chemically induced status epilepticus, there are clear signs of inflammation, reactive gliosis, and neurodegeneration (Loewen et al., 2016) as well as metabolic and redox dysregulation as reviewed by Pearson-Smith & Patel, 2017

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However, another study showed the process of ferroptosis may exacerbate proteinuria, damaging renal tubules and promoting renal fibrosis via the HIF-1/HO-1 pathway in diabetes models