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Cellular oxidative stress causes the dissociation of the complex, oligomerization of GSTP, and induction of the JNK pathway, resulting in apoptosis

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To systematically investigate the functional consequences of antioxidant treatment in human HCC cells, a panel of HCC cell lines, including MHCC-97L, PLC/PRF/5, Hep3B and HepG2, were challenged with NAC and GSH followed by various assays to measure their functional changes

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