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Tachycardia, unexplained weight loss, tremor, excessive diaphoresis, or a significantly elevated resting heart rate during or after exercise should be noted and communicated to the medical team, as they may indicate a need to adjust the dose

Transitioning from tirzepatide to retatrutide The transition from tirzepatide is similar but involves an important nuance

One is due to slowed gastric emptying

Given the effects on human metabolism, long-term use raises questions about how these treatments may reshape metabolic function, beyond therapy duration

Am J Physiol Endocrinol Metab 273: E981-988, 1997