Thyroid problems Conditions like hypothyroidism slow down metabolism, making it harder to lose weight
37 Available data suggest that increased visceral fat, rather than obesity per se , induces MS by triggering cytokine release from macrophages, activating inflammatory signaling cascades, and causing the accumulation of reactive oxygen species (ROS) resulting from endoplasmic reticulum (ER) dysfunction
Theres also the connection to taste and smell
Anecdotally, we can see that the rebound hunger is stronger when you stop suddenly versus tapering, Anekwe says
For a menopausal woman already navigating the muscle loss that estrogen withdrawal and the aging process impose, that trade-off carries significant long-term consequences
Due to fluctuations in oestrogen (which plays a key role in preserving muscle and bone mass) levels that we see in line with menopausal changes, (peri)menopausal women are already at risk of muscle loss, and 'losing weight by whatever means could reduce bone and muscle mass further, so it is important that someone taking this medication tries to optimise their diet and physical activity levels as much as possible.' Best exercises to prevent muscle loss on GLP-1s Strength training The most effective protection is resistance and strength training, says Dr Ajaz
