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The RNA-seq and qRT-PCR results for both up- and downregulated genes showed a strong positive association (r = 0.854, p = 0.007

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Compared with GPX1-3, GPX4 is also involved in the reduction of complex membrane-associated phospholipid hydroperoxides such as phosphatidylcholine hydroperoxide and cholesterol hydroperoxide, in addition to reacting with soluble, low molecular weight hydroperoxides such as t-butyl hydroperoxide and cumene hydroperoxide [68]

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Timelines vary depending on baseline skin type, dosage, and individual response