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Our findings pave the way for further evaluation of the performance of NAM toolboxes for a wider substance dataset with varied mechanisms of action, uses, and balanced low and high-risk benchmarks to build confidence in the protectiveness of the approach

Recent studies of peptide-bound, active, Gs-coupled, structures of CTR or AMYRs provide evidence supporting distinct conformations of receptors when bound to CT peptides versus amylin peptides 15 that may contribute to pharmacological differences between dual CTR and AMYR agonists

Parkinsonism Relat Disord 79:e85-86 Hauser RA, Olanow CW, Dzyngel B, Bilbault T, Shill H, Isaacson S, Dubow J, Agro A (2016) Sublingual apomorphine (APL-130277) for the acute conversion of OFF to ON in Parkinsons disease

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Park SH, Doh J, Park SI, Lim JY, Kim SM, Youn JI, et al