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The observed decrease in leucine may therefore reflect improved metabolic handling of BCAAs under ketogenic conditions

The relation between working memory components and ADHD symptoms from a developmental perspective

N Engl J Med 2020

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OHearn, A

Comparison of the homomeric and heteromeric agonist-bound non-conducting KAR structures showed global similarities in the LBD layers with subtle differences in LBD arrangement in GluK2/GluK5 compared to GluK2, illustrated by LBD dimer-dimer distance of 49.9 in GluK2/GluK5 and 54.9 in GluK2, suggesting a more compact desensitization ring in the heterotetramer ( FIGURE 8 Along with the agonist-bound structure characterized by four-fold symmetrical LBD layer, a recent study of GluK2 revealed a Glu-bound structure, where one LBD dimer was preserved, while the other LBD dimer dissociated through 100 rotation of one protomer relative to the other (Figure 8B) (Figure 4C)