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Substrate: 0.9 M Testosterone Incubation: 30 min at 37C Control Inhibitor: Dutasteride Criteria For Significance: 50% of max stimulation or inhibition Test Concentration / Dose: Suggested concentration for initial testing is 10 uM Test Sample Requirements: Minimum for 1) Screen: 25 l of 10 mM stock -OR- 1 mg (pre-weighed)

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Moreover, BBR is also able to inhibit M1 polarization in the periodontitis microenvironment, regulate the balance between M1/M2, and alleviate alveolar bone loss in periodontitis models by inhibiting the NF-B pathway (Xia et al., 2024)