Both ligands were first optimised by B3LYP/6-31 G* 42 in Gaussian 09 43 and the optimised structure was used for calculating point charges and force constants
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FIGURE 1 Among them, acute lung injury is associated with high morbidity and mortality, and can progress to acute respiratory distress syndrome with poor prognosis, with a mortality rate as high as 40% (Zhang et al., 2024)
The biodistribution of Cy5-labeled SP and Cy5-labeled SP@M was then tested by in vivo imaging measurement of fluorescence intensity using a Caliper IVIS Lumina III In Vivo Imaging System (Perkin Elmer, USA) at specific time points (0.5, 6, and 24 h post-injection) ( n = 3 in each group)
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Acetyl-CoA Donation: ALCAR can transfer its acetyl group to coenzyme A (CoA) to form acetyl-CoA, the substrate for choline acetyltransferase (ChAT), the enzyme that synthesizes acetylcholine (ACh) from acetyl-CoA and choline
