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The short half-lives of CJC/Ipamorelin mimic natural GH secretion patterns, while IGF-1 LR3s extended duration creates constant receptor activation

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With the exposure to radiotherapy, one hypothesis suggests that in individuals with higher IGF bioactivity, there is enhanced survival of partially transformed cells which leads to a larger pool of targets for subsequent hits initiating colorectal carcinogenesis via the process of stepwise carcinogenesis and malignant transformation