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The absence of a gallbladder does not fundamentally prevent these medications from working or create an automatic safety concern

If available and not contraindicated, apply a topical vasoconstrictor such as oxymetazoline (Afrin) to the bleeding nostril

doi: 10.1161/JAHA.117.006347 115 GengJYangCWangBZhangXHuTGuYet al

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This accumulation leads to ER stress-induced apoptosis and triggers the unfolded protein response (UPR) pathway in response to the misfolding of proteins within the ER