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The rate of GSH synthesis is controlled by the cell content of l-cysteine [5] and ATP, and the ratio between the two subunits of the GCL [7], as well as its feedback inhibition by GSH [8] and oxidative stimulation of GCL enzymatic activity [9]

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Second, a 13-amino acid extension is added to its N-terminus

Importantly for MCS, the two receptors modulate and sensitize each other

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