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02 Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial Eli Lilly and Company Lilly Investor Relations press release 2025 TRIUMPH-4 topline announcement, December 11, 2025: 28.7% body weight loss in the highest studied arm at 68 weeks in 445 participants

Your doctor will likely talk to you about making some lifestyle changes, mostly to how you eat

The strength increases allow productive training during caloric deficit when performance typically suffers

These medications stimulate insulin secretion from the pancreas while inhibiting the release of glucagon, leading to lower blood sugar levels

The comprehensive safety profile supports its integration into existing pharmaceutical development pipelines with minimal regulatory complexities

Because of this, it may provide benefits beyond weight loss