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1.2 Safety considerations and the limits of the GLP-1 analogy The success of GLP-1 receptor agonists should not obscure legitimate safety considerations associated with chronic peptide therapy

These neural pathways are relevant not only to eating behaviour but also to the use of addictive substances such as alcohol, opioids, nicotine and cocaine

Long-term peptide therapy is something we plan for with clear check-ins and no open-ended commitments without review

Alternative approaches include nutrient pre-loads, predominantly based on protein components

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