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10.1016/j.freeradbiomed.2018.06.031 6 BakerR

7.2 Biomarker translation: from association to utility The journey of circulating IGFBPs into clinical tools demands a rigorous, multi-stage process: Analytical Validation: The initial step requires developing standardized, reproducible assays for candidates (e.g., IGFBP-2, -4, -7) that meet regulatory guidelines for precision, accuracy, and specificity

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