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The authors propose that GHK-Cu may have blunted NF-B activation by reducing the activation of key regulators

Our results indicated that neither GHK nor GHK-Cu showed cytotoxic activity at the range of concentrations tested while CuCl 2 and Cu(OAc) 2 showed substantial cytotoxicity to the HaCaT cells at the highest concentration assayed, i.e., at 5800 M, after 30 mins treatment

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Oxidation of enzymes in the TCA cycle, electron transport chain (ETC), and -oxidation pathway also occurs following oxidative stress

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