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Because changes in basal metabolic rate play an important role in body weight homeostasis, energy expenditure (measured by indirect calorimetry) and physical activity (measured by locomotor activity) represent important parameters for gaining further mechanistic insight into anti-obesity drug effects

Regular exercise and proper nutrition support the medications effectiveness, contributing to overall well-being

GLP 1 medications directly improve insulin sensitivity by helping the body use insulin more efficiently, reducing insulin spikes after meals, and creating more stable blood sugar levels

If Ozempic hasn't worked as hoped, several factors could explain the disconnect: medication formulation differences, individual genetic variations in peptide sensitivity, or suboptimal dosing protocols