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The primary endpoint was to identify changes in plasma metabolic profiles following the GF-MKD intervention

Intracellular iron accumulation is significantly facilitated by diminished expression of ferroportin (FPN), the sole confirmed iron exporter ( - ) constitutes the initial ferroptotic signal

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The active ingredient, silibinin, is present in varying amounts, solubilities, and oral bioavailabilities in commercially available silymarin preparations (Zhu et al., 2013)