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Cortisol can affect brain function by binding to glucocorticoid receptors (GR) in the hippocampus, amygdala, and prefrontal cortex of the brain (Lv et al., 2022)

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This elevation in NAD+ levels activates critical metabolic pathways including SIRT1 (sirtuin 1), a longevity-associated protein that regulates insulin sensitivity, mitochondrial function, and cellular stress resistance

The one compound that appeared to reduce bacterial burden did so because infected macrophages were washed away after 24-h treatment, rather than through bactericidal activity against intracellular bacteria