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In theory, transdermal delivery can be effective, but it depends on the substance

Kosiborod, M

Research published in the British Journal of Pharmacology suggests that biased agonists could maintain GLP-1 receptor efficacy over longer periods, potentially making resets unnecessary

[119] conducted a phase II clinical trial in patients with NASH, that is, a placebo-controlled trial of subcutaneous sommarutide in the treatment of NASH, and found that sommarutide treatment resulted in a significantly higher proportion of patients in remission of NASH compared with placebo

However, a study by Nauck et al

Denker PS, Dimarco PE